Spironolactone for Female Alopecia

The most prevalent cause of hair thinning in women is a condition known as female pattern hair loss, also known as female androgenic alopecia. For women, losing hair may be a significant part of their identity and femininity, which could be incredibly upsetting for several reasons. Alopecia areata, also known as female pattern hair loss, is a kind of hair loss that you can treat with drugs such as Spironolactone. In this article, we will discuss Spironolactone, who can take it, how it works, and the adverse effects of the medicine.

What Is Spironolactone?

Spironolactone is a type of drug that is classified as an aldosterone receptor agonist. Because it is capable of binding to steroid receptors, it is attributed to the property of having an antiandrogenic impact. You can treat the retention of fluid caused by kidney or liver disease with spironolactone, which has been given FDA approval. Additionally, it is effective in treating heart failure, hyperaldosteronism, and excessive blood pressure. It is also a treatment for thinning hair.

Off-label use of Spironolactone is now standard practice in the medical community for treating female pattern hair loss. The information indicates that Spironolactone is the most often used anti-androgen that is not approved for managing female pattern baldness. It is because of its ability to inhibit the production of androgens.

What Effects Does Spironolactone Have on The Treatment of Hair Loss?

As was mentioned before, Spironolactone is a drug that counteracts the androgenic effects of testosterone. Spironolactone reduces the amount of testosterone in the bloodstream and minimizes testosterone’s impact on the body.

The body quickly absorbs Spironolactone after being taken, which is processed by the liver. It is subsequently converted into potassium canrenone and canrenoate, both effective aldosterone antagonists. Additionally, it reduces the amount of testosterone produced by the adrenal gland.

Although there is not a significant number of high-quality studies regarding Spironolactone for treating female pattern baldness, few trials have shown promising outcomes. A daily dose of 200 milligrams of Spironolactone was shown to prevent hair loss by approximately 62.9 % in research with a limited patient population of only four. In addition, you enhanced the overall number of hairs currently in the anagen stage of the hair development cycle.

Another trial demonstrated the synergistic advantages of taking 200 milligrams of Spironolactone and 5 percent minoxidil daily. According to a study, the combination of Spironolactone and topical minoxidil treatment is a viable choice for women whose hair loss treatment with topical therapy alone is no longer effective.

Who Is Eligible to Take Spironolactone?

Spironolactone may be helpful to many women, particularly those whose hair thinning begins before the onset of menopause. Women who suffer from female pattern hair baldness due to elevated levels of androgen production may find that using spironolactone is the most beneficial treatment option. Surprisingly enough, Spironolactone may be most helpful in treating polycystic ovarian syndrome (PCOS) in women. PCOS is an abbreviation for polycystic ovary syndrome.

However, there is a possibility of adverse effects when using this drug, particularly for pregnant or breastfeeding women. The Food and Drug Administration (FDA) now classifies Spironolactone as being in pregnancy category D, which indicates that it has the potential to cause harm to an unborn child.

If experts can demonstrate that the possible advantages to the mother substantially outweigh the potential risks to the fetus, then only then may spironolactone be administered during breastfeeding or pregnancy.

Spironolactone’s Adverse Effects On The Body

The dosage that you consume of Spironolactone can affect its side effects. Aldosterone causes the renal system to experience several side effects, including hyperkalemia, hypotension, weariness, weight loss, headaches, dry skin, and an increased desire to urinate. Because of its antiandrogenic properties, Spironolactone might also make your menstrual cycles more unpredictable and cause your breasts to feel more painful.

Spironolactone Oral Pill Side Effects

Oral pills might cause minor and severe side effects in some patients. The following tables detail several of the most common adverse reactions that could take place as a result of taking Spironolactone oral pills.

Talk to your healthcare provider or pharmacist if you have questions about the potential adverse effects of taking spironolactone pills orally. They will be able to provide you with advice on how to handle any adverse effects that could be problematic or annoying.

Note that the Food and Drug Administration (FDA) keeps tabs on the adverse effects of medications it has approved. Through the MedWatch program, you can inform the FDA about any adverse effects you may have had from using oral spironolactone pills.

A Few Minor Adverse Effects

Oral pills might cause several mild adverse effects, including the following:

  • Feeling queasy and throwing up.
  • Diarrhea
  • Tummy aches and pains
  • Confusion
  • Leg Cramps
  • Drowsiness
  • Headache
  • Dizziness
  • Issues with menstruation, such as irregular or heavy menstrual bleeding that occur after menopause
  • Sexual issues, including a diminished desire to have sexual encounters or erectile dysfunction
  • An ache in the breasts and the nipple
  • Itching

It’s possible that most of these unwanted effects will disappear in a matter of days or weeks. However, you should consult your doctor if they get worse or don’t go away.

A Few Serious Adverse Effects

While severe adverse reactions to oral pills are uncommon, they are still possible. You should contact your physician immediately if you are experiencing significant adverse effects. The following are examples of severe complications and the symptoms they cause: Extreme responses of the skin, like Stevens-Johnson syndrome.  Symptoms may include the following:

  • Rash
  • Scorching and peeling skin
  • A rash that causes blistering and peeling within your mouth, nose, eyes, or genital areas
  • Males may experience breast development.
  • Electrolyte imbalance, including hyponatremia and hyperkalemia.
  • Problems with the kidneys, including renal failure.
  • Reactions caused by allergies


Spironolactone is a well-known drug that has been around for quite some time and is rather reasonably priced. Conditions such as heart failure and excessive blood pressure are among those that it can cure. Consult your primary health care if you have any further questions or concerns.

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